Trends in Epilepsy Research
What is Lennox-Gastaut syndrome?
Lennox-Gastaut syndrome (LGS) is a form of severe childhood epilepsy that firsts manifests in children between the ages of 2 to 5 years and often persists into adulthood. Children with this syndrome have life-long behavioral, psychological and cognitive problems. There is also an increased risk of death due to uncontrolled seizures and/ injuries from sudden drop attacks.
Early infantile epileptic encephalopathies (EIEE) are a group of severe seizure disorders that occur in early childhood. Epilepsy of infancy with migrating focal seizures (EIMFS, also previously known as migrating partial seizures of infancy) is one of these.
Neurobehavioral deficits reported to originate independent of seizures in an animal model of childhood epileptic encephalopathy
Childhood epileptic encephalopathies (EEs) comprise a group of seizure disorders that manifest early in life and are commonly associated with abnormalities in cognitive, sensory and motor skills. There are various causes of childhood EEs. Injury to the brain during development of the fetus or at birth is a common cause. Thanks to recent advances in exome sequencing technology, it is increasingly evident that many rare EEs are a result of sporadic mutations in individual genes.