Cain researchers study featured in Neurology Advisor

A recent study conducted by Cain lab researchers, Dr. Anne Anderson, Angela Carter and others, presented at the 2015 American Epilepsy Society Annual Meeting in Philadelphia, was featured in the NeurologyAdvisor.com, a website that offers neurologic healthcare professionals a comprehensive knowledge base of practical neurology information and resources to assist in making the right decisions for their patients and to optimize patient outcomes.

This study shows that seizures may impact the signaling cascades necessary for long-term memory formation, and that inhibition of phosphoinositide 3-kinase (PI3K) signaling may restore seizure-induced memory deficits. The researchers were interested to understand how a single generalized tonic-clonic seizure affected learning and memory, and whether hyperactivation of the PI3K and mechanistic target of rapamycin (mTOR) cascades contributed to seizure-induced learning and memory deficits. Overall, this data suggests potential therapeutic benefits in targeting the PI3K-mTOR pathway to overcome the learning and memory deficits associated with generalized convulsive seizures.

- Rajalaxmi Natarajan, PhD, 12/09/2015