Late stage mTOR inhibition is sufficient to reverse established epilepsy

Many pediatric cases of incurable epilepsy are attributed to a congenital defect, known as cortical dysplasia (CD) in which the neurons fail to migrate to appropriate locations in the brain during development. This results in abnormal brain architecture and neuronal miswiring that manifests as severe seizures. Currently, no treatments exist to prevent this condition and the only option is to reduce seizures using anticonvulsants or neurosurgery.

An animal model of Infantile Spasms

Infantile Spasms (West Syndrome) is a severe type of childhood epilepsy. Researchers in Dr. Swann's lab have developed a rat model of infantile spasms to identify underlying causes and to develop effective therapies. Watch this video to see the strikingly similar seizure patterns experienced by this rat model and a child with infantile spasms.

Cain Labs postdoctoral fellow receives the prestigious K99/R00 grant

Dr. Matthew Weston, postdoctoral fellow at Dr. Swann’s lab received the prestigious NIH Pathway to Independence grant (K99/R00) for his research proposal titled, “Regulation of Synapse and network dynamics by mTOR”. This grant mechanism is designed to facilitate a timely and easier transition from a mentored postdoctoral research position to a stable independent research position.

Learn more about NIH Pathway to Independence grant (K99/R00).