Many roads to hyperexcitation: mTOR suppressors regulate synaptic function in different ways

Loss of 2 genes that repress mechanistic Target of Rapamycin (mTOR), a growth-promoting pathway, causes autism and epilepsy. Excessive excitation of neurons was assumed to be the culprit. However, a study published in the February 2014 issue of The Frontiers in Molecular Neuroscience adds a new twist.