Research at Cain

New study reveals how repeated early-life seizures alter microanatomy of neurons


A recent study published in eNeuro from the laboratory of Dr. John Swann, director of the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories at Texas Children’s Hospital shows how frequent seizures alter the microanatomy of neurons in the brain and that the activity of a specific enzyme may contribute to the cognitive and behavioral deficits observed in children with epileptic encephalopathies.


The Foundation for Angelman Syndrome Therapeutics features Dr. Anne Anderson's research


Dr. Anne Anderson, epileptologist at Texas Children's Hospital and investigator at the Cain Labs and Jan and Dan Duncan Neurological Research Institute. Read the blog posted on the Foundation for Angelman Syndrome Therapeutics website that describes Dr. Anderson's latest research findings on Angelman syndrome.




Abnormal high-frequency brain oscillations and infantile spasms


It is known that the human brain has its own rhythmic activity. Some of these brain rhythms are relatively slow - occurring only a few times per second while others are faster and occur 30 to 80 times every second.  However, with recent advances in electronic instrumentation it is now very clear that the brain produces even faster rhythms.  Some of these rhythms are perfectly normal like “ripples” that occur 80-200 times per second.  Others are even faster but most of these high frequency oscillations (HFOs), which sometimes occur 600 times per second, are thought to be abnormal.