Research at Cain
The brain’s balancing act: Researchers at UCSD discover how neurons equalize between excitation and inhibition
Researchers at the University of California, San Diego School of Medicine have discovered a fundamental mechanism by which the brain maintains its internal balance.
Inducing seizures in young mice leads them to show autism-like social deficits, as well as problems with learning and memory, according to a paper published in Experimental Neurology.
Excessive and synchronized nerve cell activity has long known to underlie the generation of seizures. A review published in the July 2014 issue of Advances in Experimental Medicine and Biology, proposes a novel hypothesis. It suggests that compensatory mechanisms engaged by the synapses in an epileptic brain to control run-away neuronal hyper-excitation end up having other detrimental and long-term consequences on the functioning of nerve cells, thereby impacting learning and memory.