Research at Cain
The therapeutic window for Angelman syndrome patients may be broader than previously reported
02/10/2023
Researchers at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital and Baylor College of Medicine have found that a gene therapy approach can effectively reverse key symptoms of this disorder in adult and juvenile rodent models, which demonstrates that the therapeutic age window for Angelman syndrome is much broader than reported previously and offers a new ray of hope for patients and their families impacted by this devastating disorder.
A new neurodevelopmental epilepsy disorder and its genetic cause discovered
12/16/2022
A recent study from the laboratories of Dr. Hsiao-Tuan Chao, assistant professor at Baylor College of Medicine (BCM) and investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children’s Hospital, and Dr. Pankaj Agrawal, professor at Harvard Medical School and Boston Children’s Hospital, identified alterations in the Eukaryotic Initiation Factor 4A2 (EIF4A2) gene as the cause of a novel DEE syndrome.
An animal model of West syndrome exhibits a progressive increase in epileptic spasms and learning and memory deficits
11/05/2022
Researchers in the laboratory of Dr. John Swann, professor at Baylor College of Medicine and investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, have provided the first demonstration of a progressive increase in epileptic spasms along with learning and memory deficits in an animal model of this disorder. In addition, the study published in Epilepsia, establishes this as an ‘ideal’ model to identify the underlying molecular mechanisms and to discover targeted therapies for this condition.