Research at Cain

Memory loss following a single generalized seizure is transient and reversible


A study shows that structural alterations in neurons and the resulting memory deficits that arise after a single generalized seizure can be reversed by inhibiting the Phosphoinositide 3-kinase/Akt kinase/mechanistic target of rapamycin (i.e. PI3K/Akt/mTOR) signaling pathway. 


New study reveals how repeated early-life seizures alter microanatomy of neurons


A recent study published in eNeuro from the laboratory of Dr. John Swann, director of the Gordon and Mary Cain Pediatric Neurology Research Foundation Laboratories at Texas Children’s Hospital shows how frequent seizures alter the microanatomy of neurons in the brain and that the activity of a specific enzyme may contribute to the cognitive and behavioral deficits observed in children with epileptic encephalopathies.


Abnormal high-frequency brain oscillations and infantile spasms


It is known that the human brain has its own rhythmic activity. Some of these brain rhythms are relatively slow - occurring only a few times per second while others are faster and occur 30 to 80 times every second.  However, with recent advances in electronic instrumentation it is now very clear that the brain produces even faster rhythms.  Some of these rhythms are perfectly normal like “ripples” that occur 80-200 times per second.  Others are even faster but most of these high frequency oscillations (HFOs), which sometimes occur 600 times per second, are thought to be abnormal.