Trends in Epilepsy Research
West syndrome is a rare epilepsy syndrome that affects about 1 in 3000 infants. It is diagnosed based on a triad of symptoms: infantile spasms, a high-voltage, chaotic electroencephalogram (EEG) pattern called hypsarrhythmia and cognitive impairment.
Migrating partial seizures of infancy (MPSI) is a severe epilepsy syndrome that affects infants within the first six months of birth. It is characterized by focal seizures that originate from various regions in the brain, migrate to other regions and evolve into near-continuous episodes.
A recent study published in the Annals of Neurology by Dr. Lennart Mucke’s team at the Gladstone Institute of Neurological Disease in the University of California at San Francisco demonstrates that genetic ablation of tau in a mouse model of Dravet syndrome reverses most of the symptoms.