Research at Cain
A pioneering study discovers an underlying cause for infantile spasms and points to a novel therapy
05/11/2022
A groundbreaking study, conducted in the laboratory of Dr. John Swann, director of the Gordon and Mary Cain Pediatric Neurology Research Foundation labs, investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital and professor at Baylor College of Medicine, has found that the levels of insulin growth factor -1 (IGF-1) and its downstream signaling are reduced in the brains of both IS patients and animal models.
Texas Children’s researchers discover a noninvasive method to locate seizure foci in Infantile Spasms
10/20/2021
A recent study from Texas Children’s Hospital and Baylor College of Medicine finds high-frequency activity (HFA) measured with regular electroencephalogram (EEG) recordings can serve as a surrogate clinical biomarker to precisely locate areas of the brain that generate epileptic spasms in infantile spasms (IS)/West syndrome patients. In those children that are candidates for epilepsy surgery, this discovery should make it significantly easier for neurosurgeons to precisely map the abnormal region that needs to be removed. The study appeared in the journal Epilepsia.
Acthar® Gel (RCI) suppresses spasms in the TTX animal model of infantile spasms
02/05/2021
Study finds high dosages of RCI were required to eliminate spasms and hypsarrhythmia in rodents.