Research at Cain

Dissecting the roles for excitatory and inhibitory neurons in STXBP1 encephalopathy


Cain Lab researcher, Dr. Mingshan Xue, and colleagues find that the loss of the STXBP1 gene from inhibitory neurons has a more critical impact on the pathogenesis of STXBP1 encephalopathy, opening up new opportunities to develop new therapies for this disorder, which is one of the top five causes of pediatric epilepsies.


Dr. Sameer Sheth and collaborators develop a holographic tool to facilitate interactive surgical planning


The Cain Labs director, Dr. Sameer Sheth, and collaborators at Duke University, UT Southwestern, and Case Western Reserve University have developed a holographic stereotactic neurosurgery research tool (HoloSNS) that integrates patient-specific brain models into a group-based visualization environment for interactive surgical planning using connectomic hypotheses.HoloSNS currently runs on the HoloLens 2 platform and it enables remote networking between headsets. This allowed us to perform neurosurgical planning group meetings with study co-investigators distributed across the country.


Variants in PPFIA3, a synaptic scaffolding protein, discovered to be the cause of a newly recognized syndromic neurodevelopmental disorder


An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, has found that variants in the PPFIA3 gene cause a previously unknown syndromic neurodevelopmental disorder.