Research at Cain
A role for the slow oscillations of the neocortex in epileptic spasm generation
12/07/2020
Researchers from Baylor College of Medicine and Texas Children’s Hospital now provide evidence that epileptic spasms originate from the pyramidal cells in the deep layers of the neocortex. Further, they uncovered a novel neurophysiological phenomenon that explains how cortical neurons generate spasms. This is also the first study to reveal a hitherto unknown relationship between a normal brain state, like sleep, and spasms. The study was recently published in the Annals of Neurology.
FDA approves everolimus for tuberous sclerosis-associated seizures, a treatment first discovered at Texas Children's Hospital
04/20/2018
On April 10, 2018, the Food and Drug Administration (FDA) approved everolimus tablets for oral suspension (brand name: Afinitor Dispersz, Novartis Pharmaceuticals Corporation) as an adjunctive therapy to treat partial-onset refractory seizures in adults and children over 2 years of age with Tuberous Sclerosis Complex (TSC). Tuberous Sclerois isa genetic disorder that affects one million people worldwide and is characterized by benign tumors in several organs, epilepsy, behavioral problems and intellectual disability.
Altered brain expression of a specific voltage-gated ion channel in an animal model of cortical dysplasia
03/16/2018
A study published in Scientific Reports from the laboratory of Dr.